Familial hypercholesterolemia using foreign guidelines… Korea’s Optimized Diagnosis Method Appears: Science Dong-A

Presenting an expert agreement from the Korean Society for Lipid and Arteriosclerosis

Courtesy of Getty Image Bank

For familial hypercholesterolemia (FH), which is slightly different from country to country, a ‘Korean diagnostic standard’ based on clinical data from Korean patients has been published. It is expected that a more accurate diagnosis will be possible by reflecting the characteristics of domestic patients rather than foreign patients.

The Korean Lipid and Atherosclerosis Association announced on the 6th that it had confirmed the ‘agreement on familial hypercholesterolemia experts’. The agreement was published in the October issue of the Journal of the Korean Society of Lipid and Atherosclerosis and the English Journal of the Korean Society of Internal Medicine.

Familial hypercholesterolemia is an inherited disease in which blood cholesterol levels are abnormally high. Even at a young age, the receptor that removes low-density lipoprotein (LDL) cholesterol in the blood is abnormal. If left untreated, it can lead to complications such as myocardial infarction or stroke, which have a high risk of death.

According to a recent study, patients with familial hypercholesterolemia also have a high severity of novel coronavirus infection (COVID-19). The Korean Lipid and Atherosclerosis Association estimates that there are more than 100,000 patients in Korea.

Diagnosis criteria for familial hypercholesterolemia vary slightly from country to country. The Netherlands reviews five items, including family history, past history, and DNA analysis, while the United States judges based on cholesterol levels. The standard designed in Japan checks LDL levels, jaundice, and three family history items. In Korea, European and American guidelines were used.

The confirmed agreement was made based on clinical data collected in Korea over the past 10 years. The diagnosis and treatment guidelines optimized for Koreans were prepared by synthesizing Korean patient characteristics, cardiovascular disease risk, and genetic characteristics. Diagnosis criteria included LDL level, the definitive cause of the disease, coronary artery disease (CAD), family history, and the results of three gene tests, LDLR, APOB, and PCSK9.

The Korean Society of Lipid and Arteriosclerosis said, “If you suffer from familial hypercholesterolemia, the risk of developing cardiovascular disease before middle age is up to 10 times higher.”

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