6.9 C
Alba Iulia
Tuesday, July 7, 2020

Scientists identify drugs that may prevent coronavirus from jumping to uninfected cells

Must Read

Disney Research’s neural face swapping technique can provide high-resolution photorealistic video – TechCrunch

New document published by Disney Research in partnership with ETH Zurich describes a fully automated neural network-based method for...

Russia denies radiation incident despite striking measurements in Northern Europe

The registered particles, according to the international organization, are the result of a nuclear fission caused by humans. The...

The sale of AAP is finalized, which avoids the closure of an 85-year-old “ vital ” press wire

The future of the Australian Associated Press (AAP) newswire has been secured with the inking of a sale to...
Los Angeles, June 29 () Researchers have shown that the new coronavirus diverts proteins into its target cells, which could cause them to form long arm-like extensions to reach neighboring cells and advance the infection, a discovery that led to the identification of clinically approved drugs that can disrupt the process.

Scientists, including those from the European Institute for Bioinformatics at EMBL (EMBL-EBI) and the University of California at San Francisco (UCSF) in the United States, noted that viruses, including the new SARS-CoV-2 coronaviruses take control of the machinery of host cells and manipulate them to produce new viral particles.

They said that this diversion sometimes interferes with the activity of host proteins and other important molecules such as enzymes, which alter the activity of proteins by making chemical changes to its structure.

In the study, published Sunday in the journal Cell, the scientists analyzed all of the host and viral proteins that showed changes in an enzymatic process called phosphorylation after infection with SARS-CoV-2. Publicity


They explained that in phosphorylation, there is the addition of a “ phosphoryl group ” to a protein by a type of enzyme called kinase, which plays a key role in the regulation of many cellular processes, including cell-to-cell communication, cell growth and cell death.

According to the researchers, by modifying the phosphorylation patterns of host proteins, a virus can potentially promote its own transmission to other cells and, possibly, to other hosts.

They discovered that 12% of the host proteins that interact with the virus have been modified.

Publicity


The scientists also identified the kinases most likely to regulate these changes and suggested that these enzymes are potential targets for drugs to stop the activity of the virus and treat COVID-19.

“The virus prevents human cells from dividing, keeping them at a particular point in the cell cycle. This provides the virus with a relatively stable and adequate environment to continue replicating,” said Pedro Beltrao, group leader at EMBL- EBI and co-author study. One of the main conclusions of the study, scientists say, is that cells infected with SARS-CoV-2 have long, branched, arm-like extensions or filopods, which can help the virus reach neighboring cells. of the body and advancing the infection. Publicity


However, according to the researchers, more study is needed to validate these results.

“The distinct visualization of the extended branching of filopods once again explains how understanding the biology of virus-host interaction can shed light on possible points of intervention in the disease,” said Nevan Krogan, co-author of the UCSF study.

In the study, the researchers also identified dozens of drugs approved by the Food and Drug Administration of the United States (FDA) which target the kinases of interest. Publicity


They said that seven of these compounds, mainly anti-cancer compounds and inflammatory diseases, demonstrated potent antiviral activity in laboratory experiments.

“Our data-driven approach to drug discovery has identified a new set of drugs that have great potential to fight COVID-19, either alone or in combination with other drugs, and we are delighted to see s ‘They will help end this pandemic, “says Krogan. VIS VIS

LEAVE A REPLY

Please enter your comment!
Please enter your name here

This site uses Akismet to reduce spam. Learn how your comment data is processed.

Latest News

Disney Research’s neural face swapping technique can provide high-resolution photorealistic video – TechCrunch

New document published by Disney Research in partnership with ETH Zurich describes a fully automated neural network-based method for...

Russia denies radiation incident despite striking measurements in Northern Europe

The registered particles, according to the international organization, are the result of a nuclear fission caused by humans. The Swedish and Finnish nuclear authorities...

The sale of AAP is finalized, which avoids the closure of an 85-year-old “ vital ” press wire

The future of the Australian Associated Press (AAP) newswire has been secured with the inking of a sale to new owners who say they...

25 confirmed cases of COVID-19 now linked to a nail salon in Kingston, Ontario.

Kingston, Ontario area health unit confirms three more COVID-19 cases related to a nail salon in the city of eastern Ontario, warning that all...

More Articles Like This